Prof Frank Gunn-Moore:
Professor of Molecular Neurobiology, Head of School

Research Overview:

The prognosis for most neurodegenerative diseases is poor. The causes of the major diseases (eg: Alzheimer's, Parkinson's and Multiple Sclerosis) are complex, including genetic and environmental factors. All conspire to interfere with signalling pathways in neurons and glia which sustain growth and viability. My work focuses on factors that are involved in the promotion of correct neuronal function, and to do this we use a wide range of approaches that encompass biology, chemistry and physics. For more details, including my research team please see



5 (of 139 /dk/atira/pure/researchoutput/status/published available) for fjg1 (source: University of St Andrews PURE)
Please click title of any item for full details

Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment Monika Schmidt, Ondrej Benek, Lucie Vinklarova, Martina Hrabinova, Lucie Zemanova, Matej Chribek, Vendula Kralova, Lukas Hroch, Rafael Dolezal, Antonin Lycka, Lukas Prchal, Daniel Jun, Laura Aitken, Frank J Gunn-Moore, Kamil Kuca,
International Journal of Molecular Sciences 2020 vol. 21
Nanostructural diversity of synapses in the mammalian spinal cord Matthew James Broadhead, Lauren Arcinas, Sumi Bez, Fei Zhu, Jonathan Nylk, Kishan Dholakia, Frank J Gunn-Moore, Seth G.N. Grant, Gareth Brian Miles
Scientific Reports 2020 vol. 10
Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis Gordon John Florence, Frank J Gunn-Moore
International Journal of Molecular Sciences 2019 vol. 20
Light sheet fluorescence microscopy for neuroscience Stella Corsetti, Frank J Gunn-Moore, Kishan Dholakia
Journal of Neuroscience Methods 2019 vol. 319 pp. 16-27
Novel benzothiazole-based ureas as 17β-HSD10 inhibitors, a potential Alzheimer’s disease treatment Laura Aitken, Ondrej Benek, Rebecca E. Hughes, Lukas Hroch, Monika Schmidt, Louise Laura Major, Lucie Vinklarova, Kamil Kuca, Terry K Smith, Kamil Musilek, Frank J Gunn-Moore
Molecules 2019 vol. 24