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Dr James Ainge:
RCUK Fellow


Research Overview:
Dr James Ainge

Dr James Ainge
Psychology, St Mary's College
University of St Andrews
South Street
St Andrews
KY16 9JP
Fife
UK

tel: 01334 462057
fax:
room:
email: jaa7@st-andrews.ac.uk

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School of Psychology

School of Psychology and Neuroscience
Institute of Behavioural and Neural Sciences
IBANS Behavioural Neuroscience

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The focus of the lab is to try and understand the neural mechanisms that support our ability to remember the things that have happened to us – episodic memory. Most of our work takes a systems neuroscience approach to examine how networks within the hippocampus and entorhinal cortex process memory information.  We use in vivo electrophysiology to examine firing patterns of individual neurons as lab rats carry out memory tasks. We also use molecular and genetic tools to manipulate the network and understand the cellular mechanisms underlying episodic memory.

Complimenting the neuroscientific approach, other lines of research in the lab examine the cognitive mechanisms underlying episodic memory in both human adults and children. Ultimately, we aim to apply this work by using our knowledge of mammalian memory networks to help test therapeutic strategies for disorders of memory such as Alzheimer’s disease.

 


5 (of 25 /dk/atira/pure/researchoutput/status/published available) for jaa7 (source: University of St Andrews PURE)
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Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory Derek L.F. Garden, Christina McClure, Matthew Nolan, James Alexander Ainge
Current Biology 2020 vol. 30 pp. 169-175
Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease Qing Yu, Yongfu Wang, Shijun Yan, Nicola Origlia, Grazia Rutigliano, Haiyang Yu, James Alexander Ainge, Shi Fang Yan, Frank J Gunn-Moore, Shirley ShiDu Yan
Nature Communications 2018 vol. 9
The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias Imogen Callan, James Alexander Ainge, Akira Robert O'Connor
Scientific Reports 2018 vol. 8
The role of association in pre-schoolers' solutions to "spoon tests" of future planning James Alexander Ainge, Amanda Madeleine Seed
Current Biology 2018 vol. 28 pp. 2309-2313
A leptin fragment mirrors the cognitive enhancing and neuroprotective actions of leptin Yasaman Malekizadeh, Devon Redfearn, James Alexander Ainge, Gayle Helane Doherty, Jenni Harvey
Cerebral Cortex 2017 vol. 27 pp. 4769–4782