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Dr Javier Tello:
Lecturer in Pharmacology


Research Overview:
Dr Javier Tello

Dr Javier Tello
Medical and Biological Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9TF
Fife
UK

tel: 01334 463517
fax: 01334 463482
room: 208
email: jt65@st-andrews.ac.uk

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School of Medicine
Institute of Behavioural and Neural Sciences
IBANS Animal Cognition
Cellular Medicine research Division PIs

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My research interfaces cellular biology, pharmacology, and reproductive physiology, with the goal of understanding and treating fertility disorders emanating from the brain and pituitary. Neuropeptides play a critical role in a number of homeostatic processes, including metabolism, body composition, sleep/wake cycles, response to stress and ageing. However, irregular activity in any one of these processes can usurp normal reproductive function and lead to infertility.

The main goal of my research is to understand how neural networks are modulated by these peptides in the brain relevant to normal development and ageing, and to understand the molecular basis of neuropeptide signalling in both fertile and disease models.

My lab uses transgenic animals, brain slice physiology and molecular approaches to elucidate the cellular events involved with neuroendocrine responses in the hypothalamus and amygdala. We also employ state-of-the art viral vector transduction techniques (e.g. chemogenetics and optogenetics) combined with live calcium imaging and multi-labelling techniques to answer questions related to the neural circuitry underlying these physiological effects. Use of these combined techniques build a powerful arsenal for answering questions related to puberty and fertility.

Current research funding is provided by:

The Northwood Charitable Trust

The Society for Endocrinology - Early Career Grant

The Society for Endocrinology - Equipment Grant

http://www.endocrinology.org/

The British Society for Neuroendocrinology - Project Support Grant

Medical Research Scotland - Summer Studentship

 


5 (of 26 published available) for jt65 (source: University of St Andrews PURE)
Please click title of any item for full details

Medial amygdala Kiss1 neurons mediate female pheromone stimulation of luteinizing hormone in male mice Celion Tang, Kirsten Sing, Hyun Wook Kim, Robert P. Millar, Javier Ananda Tello
Neuroendocrinology 2019 vol.108 pp.172–189
Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes Andrew Morton, Caroline Murawski, Changmin Keum, Gareth Brian Miles, Javier Ananda Tello, Malte Christian Gather
Advanced Biosystems 2019 vol.3
The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration Monika Gostic, Angela Martinelli, Carl Tucker, Zhengyi Yang, Jade-Yi Ewart, Kishan Dholakia, Keith Thomas Sillar, Javier Ananda Tello, Silvia Paracchini
Journal of Comparative Neurology vol.In press
Light-sheet microscopy with attenuation-compensated propagation-invariant beams Jonathan Nylk, Miguel Preciado, Michael Mazilu, Zhengyi Yang, Frank J Gunn-Moore, Javier Ananda Tello, David Ellard Keith Ferrier, Kishan Dholakia
Science Advances 2018 vol.4
Multimode fibre based imaging for optically cleared samples Jonathan Nylk, Javier Ananda Tello, Kishan Dholakia
Biomedical Optics Express 2017 vol.8 pp.5179-5190