Dr Marcus Bischoff:

Research Overview:
Dr Marcus Bischoff

Dr Marcus Bischoff
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST

tel: 01334 467199
fax: 01334 462595
room: B115

Related Content:

Bischoff Lab Website

School of Biology
Institute of Behavioural and Neural Sciences
IBANS Animal Cognition
Biomedical Sciences Research Complex
Biology Postgraduate Committee

edit mb273 details

We are interested in how shape and form arise during animal development. During morphogenesis, cells interpret complex information and react accordingly to shape tissues and organs. Here, many cell behaviours, such as cell migration and cell shape changes, work together. Despite recent progress, it still remains mysterious how all these behaviours are regulated and coordinated.

To study cell behaviours in the living organism, we use the morphogenesis of the adult abdominal epidermis of Drosophila. Employing a combination of in vivo 4D microscopy and sophisticated genetic tools, we observe and quantify all cell behaviours after experimental manipulation of the system. We have two major areas of interest: (1) What are the signals that instruct the cells to execute certain behaviours during morphogenesis? (2) How do cells translate these signals into specific actions, such as migration and constriction? Addressing these questions will enable us to gain a deeper understanding of morphogenetic processes and the underlying cell behaviours as well as of how the mechanical forces that ultimately drive morphogenesis are created. These insights will be of widespread relevance, since the (mis-) regulation of cell behaviour is also fundamental to wound repair and numerous diseases, including cancer.


5 (of 14 /dk/atira/pure/researchoutput/status/published available) for mb273 (source: University of St Andrews PURE)
Please click title of any item for full details

Coordination of cytoskeletal dynamics and cell behaviour during Drosophila abdominal morphogenesis Anneliese Norris, Marcus Bischoff
Journal of Cell Science 2020 vol. 133
Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells Luis Alberto Baena-Lopez, Lewis Arthurton, Marcus Bischoff, Jean-Paul Vincent, Cyrille Alexandre, Reuben McGregor
Development 2018 vol. 145
In Vivo Imaging of Hedgehog Transport in Drosophila Epithelia Irene Seijo, Isabel Guerrero, Marcus Bischoff
2015 vol. 1322
Epidermal growth factor signalling controls Myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis Aditya Saxena, Barry Denholm, Stephanie Bunt, Marcus Bischoff, Krishnaswamy VijayRaghavan, Helen Skaer
PLoS Biology 2014 vol. 12
Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion Ana-Citlali Gradilla, Esperanza González, Irene Seijo, German Andrés, Marcus Bischoff, Laura González-Mendez, Vanessa Sánchez, Ainhoa Callejo, Carmen Ibáñez, Milagros Guerra, João Ramalho Ortigão-Farias, James D Sutherland, Monika González, Rosa Barrio, Juan M Falcón-Pérez, Isabel Guerrero
Nature Communications 2014 vol. 5