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Dr Samantha Pitt:
Royal Society of Edinburgh Biomedical Fellow


Research Overview:

In healthy individuals, the controlled release of calcium causes the heart to beat strongly.  Calcium is released through specialised gates called ryanodine receptors (RyR2). In patients with heart failure and fatal arrhythmias the release of calcium becomes erratic leading to weakened contraction of heart muscle and cell death. Using a combination of low noise electrophysiological recordings in combination with molecular and biochemical methods my group investigates intracellular calcium dynamics and the molecular function of RyR2 and other ion channels that are present on intracellular organelles. The aim of our research is to try to understand what happens to channel function under pathophysiological conditions.

 


5 (of 34 /dk/atira/pure/researchoutput/status/published available) for sjp24 (source: University of St Andrews PURE)
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Reduced plasma magnesium levels in type-1 diabetes associate with prothrombotic changes in fibrin clotting and fibrinolysis Amelie Isabelle Sylvie Sobczak, Fladia A. Phoenix, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart
Thrombosis and Haemostasis 2020 vol. 120 pp. 243-252
A family of Type VI secretion system effector proteins that form ion-selective pores Giuseppina Mariano, Katharina Trunk, David J. Williams, Laura Monlezun, Henrik Strah, Samantha J. Pitt, Sarah J. Coulthurst
Nature Communications 2019 vol. 10
Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets Bolin Wang, Hassane El Mkami, Samantha J. Pitt, Jason Schnell, Terry K Smith, Jonathan Lippiat, Bela Ernest Bode, Christos Pliotas
Nature Communications 2019 vol. 10
Functional characterization of ATP2C2, a risk factor for language disorders Angela Martinelli, Irene Feliciotti, Samantha J. Pitt, Silvia Paracchini
European Neuropsychopharmacology 2019 vol. 29 pp. 1194-1195
Microlaser-based contractility sensing in single cardiomyocytes and whole hearts Marcel Schubert, Lewis Woolfson, Andrew Morton, Becky Casement, Gareth Brian Miles, Samantha J. Pitt, Carl S. Tucker, Malte Christian Gather
2019