Dr Samantha Pitt:
Royal Society of Edinburgh Biomedical Fellow

Research Overview:

In healthy individuals, the controlled release of calcium causes the heart to beat strongly.  Calcium is released through specialised gates called ryanodine receptors (RyR2). In patients with heart failure and fatal arrhythmias the release of calcium becomes erratic leading to weakened contraction of heart muscle and cell death. Using a combination of low noise electrophysiological recordings in combination with molecular and biochemical methods my group investigates intracellular calcium dynamics and the molecular function of RyR2 and other ion channels that are present on intracellular organelles. The aim of our research is to try to understand what happens to channel function under pathophysiological conditions.


5 (of 29 published available) for sjp24 (source: University of St Andrews PURE)
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Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes Fiona Stefanowicz, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart
BioMetals 2019 vol.32 pp.123-138
Glycosaminoglycan neutralization in coagulation control Samantha J. Pitt, Alan J. Stewart
Arteriosclerosis, Thrombosis, and Vascular Biology 2018 vol.38 pp.1258-1270
Influence of zinc on glycosaminoglycan neutralisation during coagulation Samantha J. Pitt, Alan J. Stewart
Metallomics 2018 vol.10 pp.1180-1190
17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats Sonja Zafirovic, Milan Obradovic, Emina Sudar-Milovanovic, Alexsandra Jovanovic, Julijana Stanimirovic, Alan J. Stewart, Samantha J. Pitt, Esma R. Isenovic
Molecular and Cellular Endocrinology 2017 vol.446 pp.12-20
Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high fat diet Aleksandra Jovanovic, Milan Obradovic, Emina Sudar-Milovanovic, Alan J. Stewart, Samantha J. Pitt, Dragan Alvantic, Ema Aleksic, Esma R. Isenovic
Molecular and Cellular Biochemistry 2017 vol.436 pp.49-58